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AMPK is the body’s nutrient/energy sensor. It helps regulate many metabolic activities — from lipid, carbohydrate, and protein metabolism…to cell growth and death…to stress response pathways.

GlucodOX®, a proprietary gum extract derived from the Commiphora mukul tree and standardized to contain 2.0% guggulsterones, has been shown to enhance AMPK activity in vitro.*[s1]  It is manufactured through a unique supercritical COextraction process that recovers the active constituents, which are then dissolved in a base of medium chain triglyceride (MCT) oil for enhanced efficacy and bioavailability.

GlucodOX® shows tremendous promise for enhancing various metabolic functions, including:

  • Supporting enhanced cellular energy throughout the body*
  • Promoting joint comfort, flexibility, and function*[1]
  • Helping maintain blood sugar and lipids already within normal limits*[2],[3]
  • Promoting healthy weight control and fat metabolism*[4]





    GlucodOX® demonstrates energizing action through its ability to stimulate the production of AMPK.* [5],[6],[7] In addition, GluocodOX® promotes glucose uptake, a measure of insulin sensitivity;[8] reduces cholesterol production by inhibiting the enzyme HMG-CoA reductase;[9],[10] and supports healthy weight control by reducing the transformation of pre-adipocytes to adipocytes.*[11],[12]In vitro comparisons between GlucodOX™ and a competitive ingredient, Gugulipid®, found that GlucodOX® enhanced AMPK and inhibited HMG-CoA reductase at least twice as well as Gugulipid®.*


    Guggul resin has been used in Ayurveda, the traditional medicine in India, for thousands of years. MCT oils occur naturally in many foods such as palm kernel and coconut oils and are regularly consumed all over the world.

    [1] Singh BB, et al. Altern Ther Health Med 2003;9:74-79.

    [2] Singh RB, MA Niaz, S Ghosh. Cardiovas Drugs Ther 1994;8:659-664.

    [3] Agarwal R, et al.Indian J Med Res 1986;84:626-634.

    [4] Antonio J, et al. Curr Ther Res 1999;60:220-227.

    [5] Lage R, Dieguez C, Vidal-Puig A, Lopez M. Trends in Molec Med. 2008;14:539-49.

    [6] Long YC, Zierath JR. J Clin Invest. 2006;116:1776-83.

    [7] Steinberg GR, Kemp BE. Physiol Rev. 2009;89:1025-78.

    [8] Claudel T, Staels B, Kuipers F. Arterioscler Thromb Vasc Biol. 2005; 25(10):2020-30.

    [9] Izzat NN, Deshazer ME, and Loose-Mitchell DS.  Perspectives in Pharmacology. 2000; 293(2): 315-20.

    [10] Urizar NL, Liverman AB, Dodds DT, Science. 2002;296:1703-7.

    [11] Yang J-H, Della-Fear MA, Rayalam S, Ambati S, Baile CA. BioFactors. 2008;30:159-69.

    [12] Rizzo G, Disante M, Mencarelli, Mol Pharmacol. 2006; 70:1164-73.