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Proteoglycans are a component of connective tissues such as bone, cartilage, and skin. Made from proteoglycans extracted from the cartilage of salmon, Juvecol is a NEXTY Award winning ingredient clinically documented to support joint health and skin beauty.*
The effect of salmon cartilage proteoglycans (sPG) on joint health was evaluated in a randomized, placebo-controlled, double-blind human clinical trial. Supplementation for 12 weeks supported joint comfort and mobility (improving both extension, the degree to which a joint can extend, and flexion, the degree to which a joint can bend).*
Another randomized, placebo-controlled, double-blind human study found sPG improved multiple indices of skin condition after just two weeks, including elasticity, moisture, and appearance (reducing blotchiness, wrinkles, and pore size).*
There are several hypotheses regarding how sPG works.
Skin: sPG induces the production of collagen and hyaluronan and enhances the proliferation of keratinocytes (skin cells).*
Joints: sPG spurs the production of chondrocytes (cartilage cells) by helping them proliferate and differentiate.*
Skin and joints: sPG also stimulates immunity in the gut and lymphatic system, which helps maintain a balance of excitatory and inhibitory cytokines.*
In Japan, salmon cartilage is consumed as a traditional tonic for joint health and general health. Numerous animal studies on purified proteoglycan, including a 90-day repeated dose toxicity study in rats, have shown no adverse effects and found it is safe for human consumption.
 Takahashi T, et al. Immune Endo and Metab Agents in Med Chem. 2015;15:160-7.
 Takahashi T, et al. Pharmacometrics. 2015 Jul;89(1-2):15-22.