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Juvecol®

Proteoglycans are a component of connective tissues such as bone, cartilage, and skin. Made from proteoglycans extracted from the cartilage of salmon, Juvecol is a NEXTY Award winning ingredient clinically documented to support joint health and skin beauty.*

The effect of salmon cartilage proteoglycans (sPG) on joint health was evaluated in a randomized, placebo-controlled, double-blind human clinical trial. Supplementation for 12 weeks supported joint comfort and mobility (improving both extension, the degree to which a joint can extend, and flexion, the degree to which a joint can bend).*

Another randomized, placebo-controlled, double-blind human study found sPG improved multiple indices of skin condition after just two weeks, including elasticity, moisture, and appearance (reducing blotchiness, wrinkles, and pore size).*[1]

 

STATUS

FUNCTIONS

    MECHANISM OF ACTION

    There are several hypotheses regarding how sPG works.

    Skin: sPG induces the production of collagen and hyaluronan and enhances the proliferation of keratinocytes (skin cells).*

    Joints:  sPG spurs the production of chondrocytes (cartilage cells) by helping them proliferate and differentiate.*

    Skin and joints: sPG also stimulates immunity in the gut and lymphatic system, which helps maintain a balance of excitatory and inhibitory cytokines.*

    SAFETY

    In Japan, salmon cartilage is consumed as a traditional tonic for joint health and general health. Numerous animal studies on purified proteoglycan, including a 90-day repeated dose toxicity study in rats, have shown no adverse effects and found it is safe for human consumption.[2]

    [1] Takahashi T, et al.  Immune Endo and Metab Agents in Med Chem. 2015;15:160-7.

    [2] Takahashi T, et al. Pharmacometrics. 2015 Jul;89(1-2):15-22.

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