Hipering® Technology Transforms Challenging Powders Into Clean-Label Performance

What is Hipering®?

How It Works: Advanced Granulation Without Chemical Modification

Unlike many conventional granulation systems that rely on binders or excipient systems, Hipering® technology granulates powders into free-flowing granules without the use of excipients, while preserving ingredient purity and chemical integrity. The technology consists of a proprietary dry granulation process, followed by a compaction process that together physically transforms fine powder particles into stable, uniform granules. During processing, powders are compressed into ribbons and subsequently milled into controlled granules through sequential stages including particle rearrangement, deformation, fragmentation, and bonding.

These processes improve bulk density, compressibility, and particle size uniformity while preserving the ingredient's original chemical identity and HPLC profile. No chemical or regulatory changes occur during processing, allowing immediate dossier incorporation and maintaining ingredient stability and shelf life.

The resulting granules deliver superior rheological performance by improving powder flowability, minimizing machine adhesion, and increasing manufacturing efficiency. In select applications—for example, melatonin—the technology can also enhance dissolution and water interaction through increased surface area, resulting in improved solubility and greater formulation versatility. Complementing this approach, Hipering® utilizes an AI-driven optimization matrix to identify customized granulation parameters tailored to the unique physical and structural properties of each ingredient.

Performance Evidence

Real-world case studies demonstrate substantial improvements in flowability, compressibility, and manufacturing efficiency after Hipering® processing.

Case Study #2: Rhamnus frangula or Frangula Bark

Additional data presented for the botanical alder buckthorn; Rhamnus frangula demonstrated similar performance optimization following Hipering® treatment. The processed material showed improved particle size distribution uniformity and enhanced rheological characteristics that support smoother production runs and reduced material waste.

Operational & Manufacturing Benefits

Research demonstrates that Hipering® can deliver meaningful improvements in manufacturing efficiency and product performance, including:

Formulation & Delivery Format Advantages

Hipering® is a versatile granulation technology compatible with a wide range of nutraceutical and botanical ingredients, including CoQ10, melatonin, quercetin, magnesium citrate, L-tryptophan, and numerous plant extracts. Its excipient-free process improves powder flowability, tablet compression, capsule filling, and dissolution performance while preserving the ingredient's native chemistry.

By increasing bulk density and enabling higher active ingredient loading, Hipering® can significantly reduce tablet and capsule size without compromising potency. The result is more compact dosage forms that help address consumer pill fatigue, improve swallowing convenience, and support better compliance. At the same time, the technology simplifies manufacturing by overcoming common formulation challenges associated with poor flowability, low bulk density, particle aggregation, and difficult-to-compress ingredients.

Differentiation & Competitive Advantage

Hipering® incorporates an AI-driven optimization platform that analyzes the unique physical and structural properties of each active ingredient to identify the most effective granulation strategy. This customized approach streamlines formulation development, improves manufacturing efficiency, and helps achieve consistent product quality across a broad range of ingredient types.