In 2025, U.S. consumers are facing a growing wellness challenge: the stress–mood–sleep cycle. Chronic stress disrupts circadian rhythms and suppresses key neurotransmitters like serotonin, dopamine, and GABA—leading to poor sleep, low mood, and mental fatigue.
But here’s the good news: formulators have a unique opportunity to address all three pillars with a single, strategic approach. Research shows that improving one area—whether it’s stress resilience, mood stability, or sleep quality—can positively impact the others.
At Maypro, we offer clinically researched, proprietary, and functional ingredients that work through complementary pathways to help balance the body’s stress response system. This system—often referred to as the HPA axis—links the brain and adrenal glands to regulate cortisol, the “stress hormone.” When stress is prolonged, this system can become overactive, leading to high cortisol, imbalanced neurotransmitters, poor sleep, and reduced resilience. Our targeted ingredients help bring this system back into balance by lowering cortisol, supporting neurotransmitter synthesis, and restoring healthy sleep quality—without side effects or dependency. These solutions are ideal for premium standalone products or synergistic multi-ingredient blends targeting stress, mood, and restorative sleep.
Venetron®: Natural Relief for Stress, Mood, and Sleep
Venetron® is a proprietary extract of Apocynum venetum leaves, rich in flavonoids like hyperoside and isoquercitrin. It’s been shown to:
- Reduce chormogranin A (a stress biomarker)
- Increase serotonin
- Improve sleep and mood without affecting CYP3A or P-glycoprotein
Clinical Highlight
A recent 6-week, double-blind, placebo-controlled study of 270 cohorts found that 50 mg of Venetron® daily significantly improved perceived stress and sleep quality in adults with anxiety.
Discover how Venetron® can elevate your formulations.
Download the Venetron Infographic
MicroActive® Melatonin: Advanced Two-Phase Delivery for All-Night Sleep Support
Most melatonin supplements wear off too soon—leaving users awake in the middle of the night. MicroActive® Melatonin solves this with patented sustained-release technology that delivers a consistent dose over 7–8 hours, syncing perfectly with the body’s natural sleep cycle.
How it works:
- 40% released in the first hour for fast sleep onset
- 50% released gradually over 5 hours for sustained sleep
- 10% released at 7 hours to support natural waking
This two-phase delivery system uses micronization for fast absorption and encapsulation for controlled release—ensuring restful sleep and refreshed mornings.
Explore the science behind MicroActive® Melatonin.
Sucrosomial® Magnesium: Advanced Delivery for Brain, Mood & Sleep Health
Magnesium plays a key role in over 300 enzymatic reactions, including those that regulate neurotransmitters and stress hormones. But conventional forms often fall short due to poor absorption and GI discomfort.
Sucrosomial® Magnesium uses Sucrosome® technology to encapsulate magnesium oxide in a matrix of phospholipids and sucresters, allowing for:
- Enhanced bioavailability
- Faster uptake and higher plasma levels
- Improved GI tolerability
This makes it a clinically validated solution for stress resilience, sleep quality, cognitive health, and mood support.
Unlock Calm and Clarity with ETAS®: The Power of Heat Shock Protein 70
ETAS® is a novel, enzyme-treated asparagus stem extract that helps reduce stress, improve sleep, and support mood. It naturally boosts Heat Shock Protein 70 (HSP70)—a vital cellular protector that enhances brain and body resilience.
Clinical Snapshot
A daily 300 mg dose of ETAS® has been shown to:
- Increase HSP 70
- Lower cortisol
- Improve sleep quality
- Enhance cognitive clarity
- Promote emotional balance
Think of it as the natural stress relief of a hot spring—without the side effects.
Let's Talk Formulation Strategy
If you’re looking at new ways to support stress, mood, and sleep in your product line, I’d be happy to connect. Our team can help you:
- Review the clinical research
- Explore synergistic ingredient combinations
- Customize solutions tailored to your brand
We’d be glad to set up a call with our technical team to discuss how these ingredients can best fit into your formulations. If you will be at SupplySide Global in October, we can also schedule a time to meet. Just reply to this email to reach me directly and we can find a time that works.
Maypro® is here to support your next innovation in wellness. Together, we can develop products that make a real impact.
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