A proprietary strain of Akkermansia muciniphila, clinically shown to support metabolic health, gut barrier integrity, and immune function.

A healthy microbiome does more than support digestion—it’s a central hub for overall wellness. From immune function and mental wellbeing to digestive balance, the gut plays a vital role in keeping the body in harmony.

Recent research has revealed the microbiome pivotal role in metabolic health. The digestive system helps regulate key processes including:

• ✅ Metabolic hormones
• ✅ Blood sugar levels
• ✅ Blood lipids
• ✅ Body weight and composition

This connection opens the door for commensal probiotics that support metabolic wellness, helping consumers achieve their goals for weight, body composition, and healthy blood lipid levels.

AKKERMANSIA MUCINIPHILA: A FOUNDATIONAL PROBIOTIC

Akkermansia muciniphila is emerging as a breakthrough gut bacterium with unique metabolic benefits. Its AKK PROBIO’s ability to degrade mucin—a key glycoprotein in the gut’s mucus layer—offers multiple advantages:

• Strengthens the gut barrier: Stimulates mucin production, reinforcing intestinal health.
• Supports gut energy: Generates short-chain fatty acids (SCFAs) such as acetate and propionate, which fuel colonocytes and promote gut function.
• Enhances metabolic regulation: Promotes the secretion of gut hormones—including GLP-1, leptin, and peptide YY—to support insulin sensitivity, healthy blood sugar, appetite regulation, and reduced fat storage.

THE AKK PROBIO™ ADVANTAGE

AKK PROBIO™ represents the next generation of probiotics. What sets this foundational strain of Akkermansia muciniphila apart from other probiotics is its clinically validated benefits, well-defined mechanisms of action, and its availability in both probiotic and postbiotic forms.

Both the live probiotic and inactivated postbiotic forms of AKK PROBIO™ have been shown to shift the gut microbiome toward a healthier balance, increasing the abundance of beneficial bacteria and reducing less favorable species. These shifts in microbial composition and diversity help create a healthier intestinal ecosystem, which in turn support metabolic health and gut barrier integrity.

AKK PROBIO™ LIVE

The live form is manufactured using proprietary technology that protects the bacteria after fermentation, shielding it from oxygen and ensuring long-term stability and viability. This makes it ideal for capsule delivery while preserving the strain’s ability to actively degrade mucin and produce short-chain fatty acids (SCFAs), which help stimulate GLP-1 secretion and promote metabolic regulation.

AKK PROBIO™ INACTIVE

The postbiotic form offers a stable, versatile alternative. Heat inactivation addresses the common challenge of oxygen sensitivity in live Akkermansia, enabling broader application in functional foods, beverages, gummies, powders, and fast-melt formats without compromising efficacy.

Even though the postbiotic is no longer metabolically active, research shows it retains two key functional components, including:

• Amuc_1100: An outer membrane protein that stimulates mucin production, strengthening the gut barrier and supporting a healthy microbial environment.
• P9: A secreted protein that promotes GLP-1 release from L-cells, supporting blood sugar regulation and metabolic health.

While the live strain provides the added benefit of active mucin degradation and SCFA production, the postbiotic form delivers substantial benefits through these preserved bioactive proteins, making it a reliable, flexible delivery solution for promoting metabolic balance and gut health.

As a result, both forms of AKK PROBIO™:

• ✅ Aid weight maintenance*
• ✅ Support a healthy body composition*
• ✅ Help maintain healthy levels of triglycerides*
• ✅ Encourage emotional well-being and sleep quality*
• ✅ Support healthy liver function*

AKK PROBIO™ RESEARCH

Supported by 15 patents and 7+ scientific studies, AKK PROBIO™ is currently being evaluated in a wide range of exciting clinical trials, demonstrating the versatility and potential of Akkermansia muciniphila to positively impact metabolism, emotional health, hormonal imbalance, and muscle maintenance.

In a placebo-controlled, 8-week clinical trial involving 130 overweight volunteers, both the probiotic and postbiotic versions of AKK PROBIO™ delivered promising results.*1

• Increased levels of the key appetite-regulating hormones GLP-1, leptin, and peptide YY compared to the placebo group.*
• Supported weight loss and body fat reduction.*
• Maintenance of healthy triglyceride levels.*
• Reported benefits to mood and sleep quality*
• Supported healthy liver function through reductions in serum ALT and AST levels.*
• The probiotic version also supported healthy total and LDL cholesterol levels.*

AKK-PROBIO™: LIVE AND POSTBIOTIC AKKERMANSIA, PRECISELY STANDARDIZED BY AFU

Maypro offers both a live and postbiotic form of Akkermansia muciniphila with industry competitive level of cell standardizations. The live form are viable and are protected by a shell coating to ensure their viability in oxygen rich environments, while the postbiotic is carefully pasteurized in a process which maintains its membrane integrity.

In order to assess and confirm the industry competitive level of Akkermansia muciniphila cells, AKK Probio is tested and quantified using flow cytometry. This method can measure the number of cells with with intact membranes in an accurate manner. Hence thelive AKK

Probio is standardized through Active Fluroescent Units (AFU), whereas the postbiotic versions of AKK Probio are standardized to inactive flourescent units (n-AFU). Both grades are guaranteed to provide the optimal cells of Akkermansia muciniphila, to provide its beneficial effects within the microbiome. Together, these dual-standardized formats ensure consistent delivery of Akkermansia muciniphila cells with verified membrane integrity and functional relevance to the microbiome.

FORMS AND DELIVERY FORMATS

Live Probiotic

Postbiotic with Amuc1100 and P9

STATUS & CERTIFICATIONS

FUNCTIONS