A NEW PROBIOTIC TO DIRECTLY PRODUCE BUTYRATE FOR GUT HEALTH*

A healthy gut starts with a strong intestinal barrier—and that barrier depends on butyrate. A short-chain fatty acid (SCFA) produced when certain beneficial gut bacteria ferment dietary fiber, butyrate fuels colon cells, supports a balanced microbiome, and promotes the formation of tight junctions between cells to strengthen intestinal integrity.

Unfortunately, only about 6% of Americans consume enough fiber.¹ Low-fiber diets lead to a loss of beneficial bacteria-- particularly Anaerostripes caccae—which results in insufficient butyrate production and a weakened gut barrier.

Native to the human gut, Anaerostripes caccae is one of the few species capable of producing butyrate. Individuals with higher levels of these microbes tend to have better digestive health and fewer food sensitivities.

The CLB101™ difference

Direct butyrate production

Available exclusively through Maypro, CLB101™ is the first and only Anaerostripes caccae probiotic available for the dietary supplement market. Unlike conventional probiotics in the market such as lactobacillus or bifidobacterium species—which do not generate butyrate— CLB101™ acts as a continuous, natural source of butyrate to mimic the body’s own butyrate cycle.* In fact, Anaerostripes caccaecan supercharge conventional probiotics by converting their waste products (lactate and acetate) into butyrate.

Better than other probiotics

Most conventional probiotics support gut balance indirectly by crowding out unwanted microbes, but none produce butyrate.* CLB101™ stands apart from other probiotics, because it directly generates butyrate in the colon to support gut health.*

Better than butyrate ingredients alone

Oral butyrate (e.g., sodium butyrate) supplementation is hindered by an unpleasant smell and odor, as well as, stability issues. It is largely absorbed in the upper GI tract, so little reaches the colon. Newer forms (e.g., tributyrin) exist, but clinical evidence of meaningful outcomes remains limited, likely because the dose required for efficacious supplementation would be prohibitively large. Unlike these supplements, CLB101™ recreates the body's natural butyrate cycle with continuous biological production of butyrate directly within the lower GI tract where bacteria reside.*

Designed for real-world viability

While commercial production of many next-generation probiotics is often fraught with challenges, CLB101™ has been developed as an oxygen-tolerant powder that enables practical manufacturing, storage, and formulation while targeting delivery to the colon.

CLB101™ benefits:

• ✅ Strengthens the gut barrier*
• ✅ Maintains microbial balance*
• ✅ Supports colonization and persistence of butyrate producers
• ✅ Calms gut agitation*
• ✅ Supports a healthy immune response
• ✅ Helps manage reactions to commonly challenging foods

CLB101™ is:

• ✅ Self-affirmed GRAS
• ✅ Tested for safety
• ✅ Shelf-stable for 18 months under recommended storage conditions
• ✅ Supported by preclinical research, with a human clinical trial underway
• ✅ Protected by an exclusive worldwide license from the University of Chicago

Researched benefits

Preclinical research shows that the Anaerostipes caccaespecies—including CLB101™, its clinically developed strain—supports gut health in several ways:

• Increases butyrate concentration in the lower GI tract*

• Readily colonizes the gut for prolonged periods*²

• Helps prevent reactions to commonly challenging foods*^2,3

• Supports a healthy immune response in the gut*

Additionally, a double-blind, placebo-controlled clinical trial is underway to evaluate the safety and efficacy of CLB101™ in adults with self-reported GI issues.*

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