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Creatine is the most widely researched sports nutrition supplement available. It has been clinically shown to improve athletic performance and increase lean muscle mass, all while boasting an excellent safety profile.*
However, it can take 3-4 weeks for muscles to have full creatine saturation.
Clonapure® is a faster absorbing creatine. A perfectly balanced blend of creatine monohydrate, phosphocreatine, and phosphate, Clonapure® has been shown to have an improved time response in which it had quicker absorption into the blood compared to Creatine Monohydrate alone. This faster availability of creatine in the body suggests
Clonapure® contains phosphocreatine, the body’s preferred form of creatine for both immediate use and long-term storage. Unlike creatine monohydrate, which needs to be converted before it can be utilized, the availability of the active form of creatine, phosphocreatine allows for rapid supply and use of creatine to the body. As a result, Clonapure® demonstrates accelerated action in regenerating ATP —the primary energy source for muscle contractions, nerve impulses, and the synthesis of new molecules.*
Clonapure® is 25% more stable than creatine monohydrate, thanks to its patented composition of creatine monohydrate, phosphocreatine, and phosphate. This makes it easy to formulate into a variety of formats.
Sustained energy
In addition to two forms of creatine, Clonapure® also includes phosphate to support the ongoing conversion of creatine monohydrate into phosphocreatine inside muscle cells. This action supports sustained energy availability during repeated bouts of activity.*








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Creatine supports the production of ATP, the body’s primary energy molecule. Within muscle cells, creatine monohydrate is converted into phosphocreatine through the addition of a phosphategroup from ATP, forming ADP. When energy demand is high, phosphocreatine donates its phosphate back to ADP, rapidly regenerating ATP.
Clonapure® enhances this natural energy cycle by delivering phosphocreatine directly for immediate ATP regeneration, while also supplying creatine monohydrate and phosphate to sustain ATP production over time.*
Pre-clinical research suggests Clonapure® helps muscle cells synthesize ATP more effectively than creatine monohydrate alone.*
In 2017,The International Society of Sports Nutritionreviewed the literature on creatine andconcludedthat“short and long-term supplementation (up to 30 g/day for 5 years) is safe and well-tolerated in healthy individuals and in a number of patient populations ranging from infants to the elderly.”2
References
1. Colletti A, Pellizzato M, Hernández-Bueno A, et al. Effects of Clonapure® Supplementation on Intermittent Aerobic Capacity and Explosive Power in Elite Female Volleyball Players. Int J Sports Sci Phys Educ. 2025;10(3):115-123. doi:10.11648/j.ijsspe.20251003.15
2. Kreider RB, Kalman DS, Antonio J, et al. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr. 2017;14:18. doi:10.1186/s12970-017-0173-z