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ETAS®

ETAS is a proprietary ingredient derived from the tough lower portion of asparagus stalks, which has the unique ability to increase the production of heat shock protein 70 (HSP70).* Double-blind, placebo-controlled research has shown ETAS effectively:

  • Increases quality of sleep*[1]

  • Alleviates occasional stress by improving heart rate variability*[2]

  • Raises cognitive performance, reduces fatigue, and improves the stress response*[3],[4],[5]

The extraction process used to create ETAS results in unique hydroxymethyl furfural derivatives — particularly asfural — that are not contained in raw asparagus extract.

 

In today’s world, your stress levels can be through the roof, but while many turn to them, most stress relieving products can have drowsy and tiring side effects the next day. But what if there was a product that didn’t have these?

ETAS is an all natural asparagu extract. Derived from the tough lower portion of asparagus stalks that would otherwise go to waste, it works to relieve mental and physical stress, while also improving the quality of sleep and overall brain function.

ETAS is the world’s first dietary ingredient to deliver heat shock protein induction, allowing it to provide excellent stress relieving and fatigue reducing qualities, similar to that of hot springs, without the side effects.

What is HSP? HSP is an intracellular protein naturally produced within the body when reacting to stress. ETAS’s unique ability to produce HSP helps increase brain function by day and improve sleep quality by night.

Today is tough enough, relieve your stress with the power of ETAS.

 

We have 24 hours in a day, which most of us spend working or thinking about work. Consumers tend to turn to sleep support products to shut off their brains after a long day, but many of these products feature ingredients that leave them feeling drowsy the next day.

ETAS is an innovative stress relieving asparagus extract that developed to address these problems by being the first dietary ingredient in the world to deliver heat shock protein induction to improve stress relief to help you fall asleep, and improve brain function to help consumers tackle their day productively.

ETAS works by increasing the production of HSP — an intracellular protein produced naturally by the body when it encounters a stressor, such as extreme heat. This effect is similar to the anti-aging and stress-relieving effects of hot springs.

Derived from the tough lower portion of asparagus stalks that would otherwise go to waste, ETAS is an environmentally friendly ingredient, as well as vegan, gluten-free, and cruelty free.

 

STATUS

FUNCTIONS

    MECHANISM OF ACTION

    ETAS works by increasing the production of HSP70 — an intracellular protein produced naturally by the body when it encounters a stressor, such as extreme heat.*[6]

    HSP70 has many beneficial functions. It repairs damaged cells, tips the balance from excitatory cytokines to inhibitory ones and serves as an antioxidant.*[7],[8],[9]  Unfortunately, the heat shock response to stressors of all kinds decreases with age.[10],[11]  Human clinical research has shown that ETAS significantly increases the expression of HSP70 at a dosage of 100 mg elemental ETAS per day.*[12] (The commercially available form of ETAS is 50% elemental ETAS, requiring a dosage of 200 mg per day.)

    SAFETY

    ETAS is a natural ingredient derived from asparagus, which has been safely consumed as part of the food chain for at least 5,000 years. A 90-day toxicological study found no significant adverse events and confirmed the ingredient’s safety. [13]

    [1] Unpublished study. Hokkaido Information University, Ebetsu, Japan.

    [2] Unpublished study. Teikyo Heisei University, Tokyo, Japan.

    [3] Unpublished study. Teikyo Heisei University, Tokyo, Japan.

    [4] Sakurai T, et al. Nat Prod Commun. 2013;19(11):905-10.

    [5] Ogasawara J, et al. Nat Prod Commun. 2014; in press.

    [6] Ito T. J Agric Food Chem. 2013;61:9155-9.

    [7] Akagi R, et al. Pharmacology. 2013;91(1-2):104-11.

    [8] Doeppner TR, et al. J Cereb Blood Flow Metab. 2013 Nov;33:1778-88.

    [9] Matsuda M, et al. J Invest Dermatol. 2013 Apr;133(4)919-28.

    [10] Njemini R, et al. BMC Immunology. 2011;12:24.

    [11] Calderwood SK, Murshid A, Prince T. Gerontology. 2009;55(5);550-8.

    [12] Ito T, et al. J. Food Sci. 2014; in press

    [13] Ito T, et al. Regul Toxicol and Pharmacol. 2014;68:240-9.