The gut health revolution is here. A healthy gut does more than support digestion—it’s a central hub for overall wellness. From immune function and mental wellbeing to digestive balance, your gut plays a vital role in keeping your body in harmony. Recent research has revealed the gut’s pivotal role in metabolic health. It helps regulate key processes including:
- Metabolic hormones
- Blood sugar levels
- Blood lipids
- Body weight and composition
This connection opens the door for probiotics that support metabolic wellness, helping consumers achieve their goals for weight and body composition. Akkermansia muciniphila is emerging as a next-generation probiotic with unique metabolic benefits. Our award-winning strain of Akkermansia muciniphila, AKK PROBIO™, won the 2025 Ingredient Idol Award for Weight Management for its outstanding ability to support metabolic function, promote a healthy weight, and support a healthy microbiome.
AKK PROBIO™: Gut-Driven Metabolic Optimization
AKK PROBIO™ is a proprietary strain of Akkermansia muciniphila that was selected after years of research and the evaluation of approximately 200 Akkermansia strains. AKK PROBIO™ optimizes gut barrier integrity, supports metabolic balance, and promotes overall wellness from the inside out.
AKK PROBIO™ is uniquely available in both live probiotic and inactive postbiotic forms, each clinically validated to:
- Aid in weight management*
- Support a healthy body composition*
- Promote GLP-1 production*
- Help maintain healthy levels of triglycerides*
- Encourage emotional well-being and sleep quality*
- Support healthy liver function*
- Promote a healthy and diverse gut microbiome*
Mechanism of Action
AKK PROBIO™ works primarily by reshaping the gut microbiome towards a healthy balance. In particular, the live version of AKK PROBIO™ was shown to increase the abundance of Akkermansia muciniphila towards the level of a healthy person.* These shifts in microbial composition and diversity help create a healthier intestinal ecosystem through three key mechanisms:
- Mucin stimulation/turnover: Reinforces gut barrier integrity by triggering mucin production.
- SCFA generation: Produces acetates and proportionate to fuel colonocytes and other bacteria.
- Hormonal modulation: Stimulates GLP-1 and peptide YY - key regulators of appetite, insulin sensitivity and fat storage.
The Research
In a placebo-controlled, 8-week clinical trial involving 130 overweight adults, both live and postbiotic forms of AKK PROBIO™ demonstrated significant improvements in metabolic and emotional health, such as:
- Increased GLP-1 production
- Influences leptin production
- Greater reductions in body weight and fat mass
- Maintained healthy triglyceride levels
- Improved mood, sleep quality and liver function
Additionally, the live form of AKK PROBIO™ increased peptide YY (PYY) levels and supported healthy total and LDL cholesterol.
These results confirm AKK PROBIO™ as a powerful tool for weight management and holistic wellness. Additional clinical trials for obesity, PCOS, emotional health, and healthy aging are underway.
AKK PROBIO™ Precise Standardization
Maypro offers both a live and postbiotic form of Akkermansia muciniphila with industry competitive level of cell standardization. The live form are viable and are protected by a shell coating to ensure their viability in oxygen rich environments, while the postbiotic is carefully pasteurized in a process which maintains its membrane integrity.
In order to assess and confirm the industry competitive level of Akkermansia muciniphila cells, AKK PROBIO™ is tested and quantified using flow cytometry. This method can measure the number of cells with intact membranes in an accurate manner. Hence, our live AKK PROBIO™ is standardized through Active Fluorescent Units (AFU), whereas the postbiotic versions of AKK PROBIO™ are standardized to inactive fluorescent units (n-AFU). Both grades are guaranteed to provide the optimal cells of Akkermansia muciniphila to provide its beneficial effects within the microbiome. Together, these dual-standardized formats ensure consistent delivery of Akkermansia muciniphila cells with verified membrane integrity and functional relevance to the microbiome.
Formats
- Probiotic: The live probiotic form is oxgen-protected and retains full metabolic activity.
- Postbiotic: Heat inactivated; the inactive form is stable for functional foods, as well as soluble and heat-treated formats.
Why Choose AKK PROBIO™?
AKK PROBIO™ was selected from amongst 200 different Akkermansia muciniphila strains due to the presence of two key proteins, Amuc_1100 and P9. These proteins are involved in Akkermansia’s ability to promote mucin turnover and GLP-1 release. Additionally, AKK PROBIO™ underwent years of stability and safety research to guarantee its survivability and safety in humans.
With 15 patents and 13 published studies (and more on the way), AKK PROBIO™ offers formulators a powerful metabolic support strain in two formats—both live and inactive. Both forms enhance Akkermansia abundance and deliver clinically validated benefits across diverse applications. These dual formats are ideal for brands looking to develop a stackable, versatile, metabolic-focused product line.
AKK PROBIO™ sets a new standard for microbiome-based weight management solutions. Ready to formulate with the probiotic that’s changing the game? Let’s talk about bringing AKK PROBIO™ to your product line
