It's Time to Stress less

Looking for ingredients that tackle stress, sleep and mood? More than one in four consumers reported that they anticipate more stress at the start of 2023, with another survey finding that up to 88% of Americans feel more pressure during the holidays and at the start of a new year.

With one in three Americans not getting enough sleep and significant numbers of people feeling down or anxious, it’s clear that manufacturers have an opportunity to develop natural solutions to help consumers.

Fortunately, Maypro offers an array of powerful, science-backed proprietary branded ingredients (PBIs) that support these health areas, including Cannabid-ALL™, Venetron® and ETAS®.

Stand Out in a Crowded Market with Cannabid-ALL™!

Cannabidiolic acid (CBDA) is the main phytocannabinoid in fiber and seed-oil hemp (Cannabis sativa L.) plants, but, according to researchers, its potential health-related capabilities were overshadowed for years by a greater scientific interest in its derivative, cannabidiol (CBD).

In addition, the production of CBDA is very difficult and most extraction methods, for example those which use CO2, cannot keep CBDA from decarboxylating into CBD.

Using a patented extraction method, the natural CBDA content of Cannabid-ALL™ CBDA Complete Spectrum Hemp Extract is maintained from plant to extract, preserving more of hemp’s natural and beneficial health properties.

Cannabid-ALL features the highest amount of CBDA available, less than 0.3% THC, plus hemp flower constituents including polyphenols and chlorophyll. This makes Cannabid-ALL a full-spectrum extract.

The most complete and advanced hemp extract on the market today, Cannabid-ALL boasts the highest ratio of CBDA/CBD available, in addition to advantages over CBD, such as:

• Better absorbability
• Most complete and advanced form of CBD
• Free-flowing powder mixes easily with other powder ingredients
• Enhanced effects against stress and anxiety*
• Supports the accurate targeting of joint issues—CBDA is a selective inhibitor of the inflammatory enzyme, COX-2*

Manufactured in a Current Good Manufacturing Practice (cGMP) facility certified by UL Solutions, each batch of Cannabid-ALL is independent-laboratory tested to confirm:

• Highest content of CBDA available and naturally occurring compounds—cannabinoids, sesquiterpenes, triterpines, flavonoids, chlorophyll
• Less than 0.3% THC

Maypro is the exclusive U.S. distributor of Cannabid-ALL from supplier American BioSciences.

Cannabid-ALL is gluten-free, non-GMO, dairy-free, vegan and made in the USA from organically grown hemp flower and aerial parts.

To learn more about Cannabid-ALL, click here or talk to your Maypro representative.

Move Over St. John’s Wort—Enter Venetron®

Derived from a patented, purified, powdered extract of Apocynum venetum, Venetron® is a dietary ingredient that has great potential to improve mood.

Better yet, Venetron doesn’t impact the CYP3A pathway, unlike St. John’s wort, and is more effective at a lower dose (50 mg per day).

Mechanism of Action
Its stress-combating, mood-supporting and sleep-enhancing benefits derive from its mechanism of action, which involves reducing secretion of chromogranin A, a stress marker, and increasing serotonin levels, in this way supporting a positive outlook.*

Venetron has been shown in several placebo-controlled human clinical trials to:

• Support a positive outlook*
• Alleviate occasional stress*
• Improve sleep quality*

Venetron is believed to exert its effects in the following ways:

• Reducing secretion of chromogranin A, a stress marker*
• Working in synergy with GABA, whose main function is to calm brain excitation*
• Increasing serotonin levels, thereby boosting mood*

Venetron is dairy-free, Kosher, Halal, Self-Affirmed GRAS, and Non-GMO.

To learn more about Venetron, click here or reach out to your Maypro representative.

ETAS®— A Powerful Ingredient to Tackle Stress and Support Sleep Quality

We know that chronic and acute stress negatively impacts cognition, including memory and reasoning.*

Fortunately, research has shown that our ingredient ETAS® can support healthy stress relief, sleep, and brain function.* Better yet, ETAS is a natural extract derived from the tough lower portion of asparagus stalks that would otherwise go to waste, making the ingredient both upcycled and sustainable.

Click here to download our ETAS infographic!

The proprietary extraction process used to create ETAS asparagus extract powder results in properties that are not contained in raw asparagus extract. Double-blind, placebo-controlled research has shown ETAS effectively:

• Increases quality of sleep*
• Alleviates occasional stress by improving heart rate variability*
• Raises cognitive performance, reduces fatigue, and improves the stress response*

Mechanism of action
ETAS asparagus extract powder works by increasing the production of Heat Shock Protein 70 (HSP70) — an intracellular protein produced naturally by the body when it encounters a stressor, such as extreme heat.*

HSP70 has many beneficial functions. HSP helps proteins to ensure correct folding and it repairs damaged cells, tipping the balance from excitatory cytokines to inhibitory ones and serves as an antioxidant.* Unfortunately, the heat shock response to stressors of all kinds decreases with age.

ETAS significantly increases the expression of HSP70 at a dosage of 100 mg elemental ETAS asparagus extract powder per day. The commercially available form of ETAS powder is 50% elemental ETAS, requiring a dosage of 200 mg per day.*

In a study, participants who took 300 mg of ETAS daily for a week had three times the levels of heat shock protein HSP70 released, which is important since HSP protects our cells from stress-caused damage.*

In another study, healthy males who took ETAS showed an 80 percent reduction in cortisol levels (a stress protein) when compared to the placebo group and 2.5 times less expression of the psychological stress marker, chromogranin A, leading to better sleep.*

This is important, since getting enough sleep is vital for optimal mental functioning, too. In addition to research showing beneficial effects on mood, cellular studies have shown that ETAS supports overall brain function and improved mental focus.*

Other research found stress response improvements in the autonomic nervous system in people who took ETAS.*

ETAS is upcycled, dairy-free, Kosher, Halal, Self-Affirmed GRAS and Non-GMO.

To learn more about ETAS, click here or contact your Maypro representative.

With an increased consumer focus on the effects of mood and stress on mental well-being, 5-HTP is an ingredient that should be at the top of formulators minds.

5-HTP is a chemical byproduct of the protein building block L-tryptophan. 5-HTP works in the brain and central nervous system by increasing the production of the chemical serotonin. Serotonin can affect sleep, appetite, temperature, sexual behavior, and pain sensation.

Since 5-HTP increases serotonin levels, it is used for conditions in which serotonin is believed to play an important role.* Talk to your Maypro representative today about including 5-HTP in your supplement formula.

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