We all rely on brain power in multiple ways each day, and the brain can be considered our “command central”. Consumers are increasingly seeking supplements that support cognitive function and that preserve healthy brain function as they age.
The Effect of Brain Aging
Cognitive decline is a hallmark of aging, and more than 130 million people worldwide will experience some form of cognitive impairment by 2050. Two factors that increase risk of significant cognitive impairment are excessive amounts of reactive oxygen species (ROS) and the presence of apolipoprotein E4 (APOEε4), a gene marker of dementia risk.
This momentum reflects a broader consumer shift toward natural, science-backed solutions for gut and immune health, cognitive function, physical performance, and general wellness. Functional mushrooms are also gaining traction in categories like metabolic support, immune support, cardiovascular health, performance and beauty-from-within.
In a study, subjects with high ROS also showed presence of APOEε4. Researchers also found those with two marker APOEε4 copies had a lifetime dementia risk of almost 60%, 48% for those with one and 39% for those with none. Read more here
Not everyone who can benefit from a brain health supplement has the APOEε4 gene, however, nearly everyone contends with ROS. NeuroHD™ has been studied for its superlative brain-support abilities by scavenging ROS.
Introducing NeuroHD™
NeuroHD™ is the industry’s first complete histidine dipeptide complex that is clinically proven for neuro-cognitive protection. Histidine dipeptide (HD) is the collective term of two naturally occurring dipeptides, carnosine and anserine.
Carnosine and anserine are well-researched for promoting healthy aging, particularly of the brain, by scavenging ROS and neutralizing advanced glycation end products. Carnosine and anserine were demonstrated to reduce cognitive decline in animal studies.
NeuroHD™ is a multi-patented proprietary extract of high-purity imidazole dipeptides, which contains anserine and carnosine in a clinically proven ratio of 3:1.
NeuroHD™ helps preserve neurovascular function by increasing total cerebral blood flow and improves cognitive function by protecting brain cells from DNA damage caused by ROS sub-types. Researchers believe that it also works by inhibiting degeneration of pericytes, which maintain brain homeostasis, and supporting the health of astrocytes, which nourish neurons.
NeuroHD™ Human Clinical Evidence
Multiple human studies have found that supplementation with imidazole dipeptides as NeuroHD™ provides cognitive and neuro-protective benefits through preventing DNA damage and preserving frontal brain blood flow in individuals carrying the ApoEe4 gene.
Supplementing with 1g NeuroHD™ for three months preserved Wechsler Memory Scale-Logical Memory scores in healthy elderly volunteers and improved global Clinical Dementia Ratings in a group with mild cognitive impairment, compared to placebo.
Participants who consumed 1,000 mg total carnosine and anserine for 3 months showed better verbal episodic memory performance than those in placebo.
The NeuroHD™ group exhibited some physical changes in the brain’s network connectivity as well, prompting the researchers to suggest that daily NeuroHD supplementation can impact cognitive function and that network connectivity changes are associated with its effects.
NeuroHD™ works in combination with other nutrients. A study of middle-aged men found that 800 mg NeuroHD™ combined with 300 mg vitamin C and 20 mg of ferulic acid for 8 weeks resulted in reduced DNA damage by oxidative stress.
Creatinine-Free HD
NeuroHD® is produced through a multi-step hydrolysis and purification process designed to enrich for low-molecular-weight bioactive peptides while simultaneously eliminating non-peptidic small molecules, including creatine and creatinine, which are naturally present in the raw animal source materials (e.g., chicken and salmon tissues).
This purification process ensures that NeuroHD® is free from residual creatine and creatinine, making it suitable for individuals with renal impairment or those monitoring serum creatinine levels.
Additionally, the patented extraction technology removes fish/chicken flavors enabling the ability to formulate in applications that include beverages, gummies, stick packs and chews without the need for masking ingredients. As shown through human studies, the effective dose of NeuroHD™ is 1 g for brain and cognitive function support.
Smart Support for Brain Health
When formulating for consumers seeking long-term support for healthy brain function, NeuroHD™, which protects the brain from excessive free radical damage – even for those with the gene increasing dementia risk -- is the sensible solution.
Functions
- Brain Health
- Healthy Aging
- Antioxidant
To learn more about NeuroHD™, click here.
